Selecting one of the KEGG Pathways below and clicking submit will open a new window displaying a PDF file. The first page of that file is a clustered heatmap that clusters MelanomaDB's 310 tumours by their mutational status in the genes of the selected KEGG Pathway. The intersection between the tumour name (on the y-axis) and the gene name (on the x-axis) is highlighted blue if that tumour contains a mutation in that gene that affects its encoded protein's sequence.

In addition, four annotations are given for each gene:

• 'Drug' indicates which genes encode proteins targeted by a drug (according to DrugBank)


• 'Druggability' indicates which genes encode proteins that are predicted to be druggable (according to ChEMBL DrugEBIlity's Ensemble score)


• 'Variant incidence' indicates genes with protein affecting mutations in more than 1% (orange) and more than 5% (red) of the 310 MelanomaDB tumours.


• 'Survival' indicates those genes with RNA abundance associated with survival according to our analysis of the data of Bogunovic et al 2009, so that the Cox proportional hazards p value for association between RNA abundance and patient survival is ≤ 0.05 without multiple testing correction.

The rest of the PDF file shows the selected KEGG Pathway for each individual tumour, with genes with mutations affecting their protein sequences highlighted in yellow. Genes that encode proteins that are targeted by an existing drug are shown with red outlines and labels.

Please note that the result files can be big. This can lead to a long wait with a slow internet connection. The tool will tell you the size of the file if it is bigger than 25 MB and will ask you to confirm the process.

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Acute myeloid leukemiaAdherens junctionAdipocytokine signaling pathwayAfrican trypanosomiasisAldosterone-regulated sodium reabsorptionAllograft rejectionalpha-Linolenic acid metabolismAlzheimer's diseaseAmino sugar and nucleotide sugar metabolismAminoacyl-tRNA biosynthesisAmoebiasisAmyotrophic lateral sclerosis (ALS)Antigen processing and presentationApoptosisArachidonic acid metabolismArginine and proline metabolismArrhythmogenic right ventricular cardiomyopathy (ARVC)Ascorbate and aldarate metabolismAutoimmune thyroid diseaseAxon guidanceB cell receptor signaling pathwayBacterial invasion of epithelial cellsBasal cell carcinomabeta-Alanine metabolismBile secretionBiotin metabolismBladder cancerButanoate metabolismCaffeine metabolismCalcium signaling pathwayCarbohydrate digestion and absorptionCardiac muscle contractionCell adhesion molecules (CAMs)Cell cycleChagas disease (American trypanosomiasis)Chemokine signaling pathwayChronic myeloid leukemiaCysteine and methionine metabolismECM-receptor interactionEndocrine and other factor-regulated calcium reabsorptionEpithelial cell signaling in Helicobacter pylori infectionEther lipid metabolismFat digestion and absorptionFatty acid biosynthesisFatty acid metabolismFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisFocal adhesionFolate biosynthesisFructose and mannose metabolismGalactose metabolismGap junctionGastric acid secretionGliomaGlutathione metabolismGlycerolipid metabolismGlycerophospholipid metabolismGlycine, serine and threonine metabolismGlycosaminoglycan degradationGlycosphingolipid biosynthesis - globo seriesGlyoxylate and dicarboxylate metabolismGnRH signaling pathwayGraft-versus-host diseaseHedgehog signaling pathwayHepatitis CHistidine metabolismHuntington's diseaseHypertrophic cardiomyopathy (HCM)Inositol phosphate metabolismInsulin signaling pathwayIntestinal immune network for IgA productionJak-STAT signaling pathwayLeishmaniasisLeukocyte transendothelial migrationLinoleic acid metabolismLipoic acid metabolismLong-term depressionLong-term potentiationLysine biosynthesisLysine degradationLysosomeMalariaMAPK signaling pathwayMaturity onset diabetes of the youngMeaslesMelanogenesisMelanomaMineral absorptionmRNA surveillance pathwaymTOR signaling pathwayNatural killer cell mediated cytotoxicityNeuroactive ligand-receptor interactionNeurotrophin signaling pathwayNicotinate and nicotinamide metabolismNitrogen metabolismNOD-like receptor signaling pathwayNon-small cell lung cancerNotch signaling pathwayOlfactory transductionOne carbon pool by folateOocyte meiosisOsteoclast differentiationp53 signaling pathwayPancreatic cancerPancreatic secretionPantothenate and CoA biosynthesisParkinson's diseasePathogenic Escherichia coli infectionPathways in cancerPentose and glucuronate interconversionsPentose phosphate pathwayPhagosomePhenylalanine metabolismPhenylalanine, tyrosine and tryptophan biosynthesisPhototransductionPorphyrin and chlorophyll metabolismPPAR signaling pathwayPrimary bile acid biosynthesisPrion diseasesProgesterone-mediated oocyte maturationPropanoate metabolismProstate cancerProtein processing in endoplasmic reticulumProximal tubule bicarbonate reclamationPyruvate metabolismRegulation of actin cytoskeletonRegulation of autophagyRenal cell carcinomaRheumatoid arthritisRibosome biogenesis in eukaryotesRIG-I-like receptor signaling pathwayRNA degradationRNA transportSalivary secretionShigellosisSmall cell lung cancerSNARE interactions in vesicular transportSphingolipid metabolismStaphylococcus aureus infectionStarch and sucrose metabolismSteroid biosynthesisSteroid hormone biosynthesisSulfur metabolismSulfur relay systemSynthesis and degradation of ketone bodiesSystemic lupus erythematosusT cell receptor signaling pathwayTaste transductionTaurine and hypotaurine metabolismTerpenoid backbone biosynthesisTGF-beta signaling pathwayThiamine metabolismThyroid cancerTight junctionToll-like receptor signaling pathwayToxoplasmosisTryptophan metabolismType I diabetes mellitusType II diabetes mellitusTyrosine metabolismValine, leucine and isoleucine biosynthesisValine, leucine and isoleucine degradationVascular smooth muscle contractionVasopressin-regulated water reabsorptionVEGF signaling pathwayVibrio cholerae infectionViral myocarditisVitamin B6 metabolismVitamin digestion and absorptionWnt signaling pathway