MelanomaDB

MelanomaDB Help Page

Despite on-going research, metastatic melanoma five year survival rates remain low and treatment options limited. Researchers can now access a rapidly growing amount of molecular and clinical information about melanoma. This information is becoming increasingly difficult to assemble and interpret due to its dispersed nature, yet as it grows it becomes increasingly valuable for understanding melanoma biology and clinical progression. Integration of this information into a comprehensive resource to aid rational experimental design and patient stratification is needed. We have assembled a web-accessible melanoma- focused database that incorporates clinical and molecular data from several sources, which will be regularly updated as new information becomes available. The way this database is constructed, information about melanoma is incorporated as gene sets (e.g. one gene set could be those RNAs for which expression level in metastatic melanomas is significantly associated with patient survival). This melanoma- associated gene set database allows complex links to be drawn between: the genetic changes in individual melanomas revealed by DNA sequencing, associations between gene expression and patient survival, data concerning drug targets, biomarkers, druggability and clinical trials, as well as statistical analysis of relationships between molecular pathways and clinical parameters using these data sets. Several drug and biomarker gene sets are included in particular to allow the identification of novel druggable molecules associated with melanoma development or progression. The database is freely available. Detailed instructions for this database's' use can be found in the Help link at the top of this page. Please go to either of the links below to start using the database. This database was last updated on 20 May 2013. Current version 2.0.

http://genesetdb.auckland.ac.nz/melanomadb

Go to the link below if you simply want to see whether your own gene list has statistically significant enrichment for any melanoma-associated gene sets.

http://genesetdb.auckland.ac.nz/melanomadb/haeremai.php

If you need help please don't hesitate to contact us (bioinformatics@auckland.ac.nz).

General information about the gene sets.